Dutasteride to Treat BPH Patients and Reduce Bladder Obstruction


Benign prostatic hyperplasia (BPH) causes lower urinary tract symptoms (LUTS) due to bladder outlet obstruction (BOO) and overactive bladder (OAB). Treatment with dutasteride, a 5α-reductase inhibitor, improves LUTS but the mechanisms behind its mode of action remain to be elucidated. Researchers at Department of Renal and Urologic Surgery of the Asahikawa Medical University found a correlation between clinical improvement and bladder vascular resistance before and after dutasteride treatment in BPH patients with LUTS. These results seem to explain the beneficial role of dutasteride in bladder symptoms and were published in a study entitled “Improvement of Overactive Bladder Symptoms and Bladder Ischemia with Dutasteride in Patients with Benign Prostatic Enlargement” in the journal LUTS.

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