Benign prostatic hyperplasia (BPH), also known as prostate enlargement, swollen prostate, or prostatic hypertrophy, is a disease that affects men. The prostate is a gland which is normally about the size and shape of a walnut and is part of the male reproductive system. As the prostate enlarges, the gland presses against and pinches the urethra, making the walls of the bladder thicker and causing urinary problems. Find out more about three key characterizations of benign prostatic hyperplasia:
1. Benign prostatic hyperplasia pathophysiological characterization: The reasons for the development of benign prostatic hyperplasia are not fully understood, but it is known that prostatic enlargement is related to the potent androgen dihydrotestosterone (DHT). The type II 5-alpha-reductase present in the prostate metabolizes, circulating testosterone and turning into DHT locally, but not systemically. Over time, DHT connects to androgen receptors in the cell nuclei, and may result in benign prostatic hyperplasia. (Read more about it here: http://bit.ly/1MpbM2z)
2. Benign prostatic hyperplasia epidemiological characterization: Worldwide, the prevalence of benign prostatic hyperplasia has risen to about 30 million men who experience the symptoms. Despite the fact the prevalence of benign prostatic hyperplasia in whites and African-Americans is similar, it is usually more severe and progressive among African-Americans. This may be explained by higher levels of testosterone, 5-alpha-reductase activity, and androgen receptor expression, as well as growth factor activity in this population that leads to an increased rate of prostatic hyperplasia and enlargement. (Read more about it here: http://bit.ly/1MpbM2z)
3. Benign prostatic hyperplasia physical characterization: The main symptoms associated with benign prostatic hyperplasia include urinary frequency, the equivalent to urinating eight or more times a day; urinary urgency, which is the inability to delay urination, trouble starting a urine stream; a weak or an interrupted urine stream among others. These symptoms are usually related to a blocked urethra and / or a bladder that is overworked from trying to pass urine through the blockage. (Read more about it here: http://bit.ly/1MpbM2z)
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