Study Explores Prostate Hyperplasia Correlations in Indonesia

Study Explores Prostate Hyperplasia Correlations in Indonesia

Researchers looked at age, prostate specific antigen (PSA) and prostate volume (PV) in Indonesian males with benign prostatic hyperplasia (BPH) and determined that the relationship between the variables was similar to other population sets – PV and PSA rose with age and prostate volume correlates with PSA.

The study, “Relationship of age, prostate-specific antigen, and prostate volume in Indonesian men with benign prostatic hyperplasia,” was published in Prostate International.

In BPH, significant tissue remodeling occurs within the prostate as men age, which induces an increase in PV. Several studies from Western and East Asian populations also explored the relationship between PSA and PV which demonstrated a positive correlation.

For the current study, researchers examined data of 1,638 men in Indonesia, age 40 and older, and diagnosed with BPH between June 1994 and December 2013. All patients complained of lower urinary tract symptoms (LUTS) and were subjected to TRUS-guided prostate biopsy.

Patients who had their PSA levels above 10 ng/mL were eliminated because of potential prostate cancer. TRUS was used to measure PV, then proper statistical tests were used for data analysis.

The results reveal statistical significant differences in PSA and PV between age groups.

Analysis of the data by subgroup (with versus without) the use of a catheter inserted into the bladder revealed the following: age (66.09 versus 65.38), PSA (4.93 ng/mL versus 4.68 ng/mL), and PV (47.58 versus 41.43).  Catheter use had no effect between the categories.

The study concluded: “In Indonesian men with biopsy-proven BPH, both PV and PSA increased with ageing. Prostate volume was significantly correlated with PSA. Even though the results were weaker, these results are consistent with results in other sets of population. The results vary between different countries and thus, ethnicities. Indonesia is a populous a sociocultural and ethnically diverse country. Therefore, aside from PSA, age, and PV, when investigating men with BPH, ethnicity may also need to be taken into account.”

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Malika Ammam received her MS degree from the University of Pierre et Marie CURIE in July 2002 and her PhD from the University of Paris Sud XI, France in September 2005. From 2006 to 2007, she worked as a research fellow at the University of Kansas in collaboration with Pinnacle Technology Inc. (USA). From 2007 to 2010, she was a research associate at KU Leuven, Belgium. From 2010 to 2012, she worked at the University of Ontario Institute of Technology in collaboration with Alcohol Countermeasure Systems Corporation, Canada. She held a prestigious Rosalind Franklin fellowship and resigned in 2015. Now, she is a freelancer.

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